Prostate-specific antigen concentrations in serum in acute illnesses
| Autor: | Nadhipuram V. Bhagavan, L. Cody, Cheryl E. Sugiyama, T. Morita, Carlos N. Rios, Stacey A.A. Honda, A. P. Goldstein |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
business.industry Biochemistry (medical) Clinical Biochemistry Acute-phase protein Alpha (ethology) urologic and male genital diseases Serum samples Spearman's rank correlation coefficient Blood proteins Prostate-specific antigen Endocrinology medicine.anatomical_structure Antigen Prostate Internal medicine medicine business |
| Zdroj: | Clinical Chemistry. 42:1785-1788 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/42.11.1785 |
| Popis: | In light of recent studies showing that prostate-specific antigen (PSA) complexes with certain blood proteins, we studied the effects of acute-phase reactants and alpha 2-macroglobulin (A2MG) on serum concentrations of PSA. Serum samples were obtained from 419 men admitted to an acute-care facility. Various acute-phase reactants-including C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin, and alpha 1-antichymotrypsin-and A2MG were measured with a Beckman Array analyzer in parallel with determinations of PSA concentrations by two methods, the Hybritech Tandem RIA and the Abbott PSA IMx. Evaluation by Spearman rank correlation revealed a significant negative correlation of A2MG with PSA values (P < 0.01) and (as expected) a positive correlation of age with PSA values (P < 0.001). The former correlation suggests the possibility that patients with high serum concentrations of A2MG may give falsely decreased results for PSA concentrations in serum. |
| Databáze: | OpenAIRE |
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