Vitamine D et rein
| Autor: | Etienne Cavalier, Marie Courbebaisse, Eric Thervet |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Calcitriol business.industry Kidney metabolism Parathyroid hormone General Medicine urologic and male genital diseases Transplantation chemistry.chemical_compound Ergocalciferol Endocrinology chemistry Renal physiology Internal medicine Vitamin D and neurology Medicine business Cholecalciferol medicine.drug |
| Zdroj: | La Presse Médicale. 42:1391-1397 |
| ISSN: | 0755-4982 |
| Popis: | Calcitriol and analogs inhibit renin-angiotensin system, which has a pivotal role in glomerular and tubulo-interstitial damages and proteinuria, and inhibit NF-κB activation which is known to play an important role in renal diseases by promoting inflammation and fibrogenesis. Vitamin D presents interesting pleiotropic effects for the CKD patient (reduction of mortality, antiproteinuric effect and anti-inflammatory properties). "Native" vitamin D (cholecalciferol or ergocalciferol) administration in these patients also decrease parathyroid hormone levels. Native vitamin D administration in CKD patients is safe and does not lead to increased risk of vascular calcification, despite the known hypercalcemic and hyperphosphoremic properties of the molecule in its active form. Native vitamin D administration is not associated with an increased risk of renal stones, at pharmacological doses and without important concomitant administration of calcium salts. In the field of renal transplantation, experimental studies show that vitamin D analogs have a protective role against acute rejection but clinical studies remain mainly observational. |
| Databáze: | OpenAIRE |
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