Macromolecular contrast media. A new approach for characterising breast tumors with MR-mammography

Autor:	Werner Rosenau, M. Wendland, R. C. Brasch, Andreas Mühler, Axel Gossmann, Timothy P.L. Roberts, Heidi C. Roberts, H. E. Daldrup
Rok vydání:	1997
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test Tumor differentiation business.industry Diagnostico diferencial Mammary gland medicine.disease Breast tumor medicine.anatomical_structure Carcinoma Medicine Mammography Radiology Nuclear Medicine and imaging business Mr mammography
Zdroj:	Der Radiologe. 37:733-740
ISSN:	1432-2102 0033-832X
DOI:	10.1007/s001170050275
Popis:	The value of macromolecular contrast agents (MMCM) for the characterization of benign and malignant breast tumors will be demonstrated in this review. Animal studies suggest a high potential of MMCM to increase the specificity of MR-mammography. The concept of tumor differentiation is based on the pathological hyperpermeability of microvessels in malignant tumors. MMCM show a leak into the interstitium of carcinomas, whereas they are confined to the intravascular space in benign tumors. Capabilities and limitations of the MMCM-prototype. Albumin-Gd-DTPA, for breast tumor characterization will be summarized and compared to the standard low molecular weight contrast agent Gd-DTPA. Initial experience with new MMCM, such as Dendrimers, Gd-DTPA-Polylysine and MS-325 will be outlined. The potential of “blood-pool“-iron oxides, such as AMI-227 for the evaluation of tumor microvascular permeabilities will be discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9289892f2fe628c8b782b0f87123654a https://doi.org/10.1007/s001170050275 Zobrazit plný text záznamu Full text from SpringerLink