Characterization and enantiomer separation of indene-derived hexacyclic hydrocarbon and its application as a chiral source
| Autor: | Takashi Houkawa, Hiroaki Shitara, Yoshinori Kitahara, Shigetaka Hayano, Takuji Hirose, Koichi Kodama, Shohei Yamaguchi |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Recrystallization (geology) Cyclopentadiene 010405 organic chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Enantiopure drug Hydrocarbon chemistry Liquid crystal Drug Discovery Organic chemistry Indene Enantiomer Aromatic hydrocarbon |
| Zdroj: | Tetrahedron. 87:132082 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2021.132082 |
| Popis: | A hexacyclic chiral aromatic hydrocarbon (1), obtained by the reaction between indene and cyclopentadiene, has been characterized, and its enantioseparation has been achieved by the combination of stereoselective complexation with β-cyclodextrin and recrystallization. This method has been applied in the large-scale production of both pure enantiomers of 1. Enantiopure 1 and its derivatives have been used as chiral dopants in nematic liquid crystals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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