Paraoxonase 1 gene (Gln192-Arg) polymorphism and the risk of coronary artery disease in type 2 diabetes mellitus
| Autor: | Rania Mohamed Azmy, Mostafa Mohamed Elnajjar, Mohamed Fahmy Elnoamany, Ashraf A Dawood |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
biology Cholesterol business.industry Paraoxonase Type 2 Diabetes Mellitus medicine.disease PON1 Coronary artery disease chemistry.chemical_compound Endocrinology High-density lipoprotein chemistry Internal medicine Diabetes mellitus biology.protein medicine Gene polymorphism business |
| Zdroj: | World Journal of Cardiovascular Diseases. :29-37 |
| ISSN: | 2164-5337 2164-5329 |
| DOI: | 10.4236/wjcd.2012.21006 |
| Popis: | Background: Paraoxonase 1 (PON1) is reported to have an antioxidant and cardioprotective properties. Recently, an association of glutamine (Gln) or (type A)/arginine (Arg) or (type B) polymorphism at position 192 of PON1 gene has been suggested with coronary artery disease (CAD) among patients with diabetes mellitus (DM). However, conflicting results have also been reported. Objectives: To investigate the relationship between PON1 gene (Gln192-Arg) poly-morphism and the presence, extent and severity of CAD in type 2 DM. Methods: The study comprised 180 patients recruited from those undergoing coronary angiography for suspected CAD, who were divided according to the presence or absence of CAD and DM into 4 groups; Group I (n = 40 patients) nondiabetic subjects without CAD, Group II (n = 45 patients) diabetic patients without CAD, Group III (n = 47 patients) non diabetic patients with CAD and Group IV (n = 48 patients) diabetic patients with CAD. PON1 (Gln192-Arg) genotype was assessed using polymerase chain reaction (PCR) followed by AlwI digestion. Results: The frequency of Gln allele (Type A) was significantly higher in group I and group II compared to group III and group IV (62.5%, 60% vs 38.3%, 31.25% respectively, p 100 mg/dL [OR 4.31, CI (1.25 - 12.5), P < 0.001], high density lipoprotein (HDL) cholesterol |
| Databáze: | OpenAIRE |
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