Experimental and Empirical Characterization of Reversed Phase Media
| Autor: | C. Hopper, Nicoleta Tarfulea, Anita M. Katti |
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| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Journal of Liquid Chromatography & Related Technologies. 32:348-369 |
| ISSN: | 1520-572X 1082-6076 |
| DOI: | 10.1080/10826070802631428 |
| Popis: | Characterization of solute, stationary phases, and mobile systems faces its challenges. This challenge touches on 5 characteristics studied herein. One, evaluate the effective particle diameter as a function of methanol–water composition. The objective is to use the effective particle size as measured by the pressure drop as a characteristic feature of the particle size for raw material testing. This is an alternative or improvement to using a characteristic of the particle size distribution. An effective particle diameter was measured at 3 microns for a nominal 5 micron material, indicative of a good particle size distribution. Two, quality parameters evaluated were precision, linearity, limit of detection, and limit of quantitation. Three, plate height data is measured as a function of flow rate in methanol-water with toluene as a probe solute. The data is evaluated by classic plate count models. Four, an improvement is made in the least square error, having a value of 10, for the van Deemter m... |
| Databáze: | OpenAIRE |
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