Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation
| Autor: | Issei Takeuchi, Yukiko Ishizuka, Hiromi Uchiro, Kimiko Makino |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
inorganic chemicals
Biodistribution Liposome Polymers and Plastics 010405 organic chemistry Chemistry Cholesterol Radiochemistry chemistry.chemical_element 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Decaborane Drug delivery Cancer cell Materials Chemistry PEGylation Physical and Theoretical Chemistry 0210 nano-technology Boron |
| Zdroj: | Colloid and Polymer Science. 295:1455-1461 |
| ISSN: | 1435-1536 0303-402X |
| Popis: | Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of 10B into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40–43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 μg/g of tissue and over 5 at 8–24 h, respectively. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 μg/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral 10B amount without replacing the 11B with 10B. |
| Databáze: | OpenAIRE |
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