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This study examined the effects of both a single bout of intense exercise and 1 month of intense preseason conditioning on the expression of Toll-like receptor (TLR) proteins and signaling pathways. Eight elite Division I wrestlers were followed through the preseason training period. Blood samples were collected before preseason training started (at rest), after two weeks of training (within 30-60 minutes after completing a ~1.5 hour exhaustive exercise session) and following the pre-season training period (at rest). After the collection of blood samples from the athletes, peripheral blood mono-nuclear cells (PBMC) were separated from the whole blood samples. Messenger RNA was isolated from the PBMC’s and TLR focused gene expression was measured using DNA microarray. Illness records were collected over the wresting season. The microarray results demonstrated a significant change (p |
