Comparison of two HPLC techniques for monitoring enantioselective reactions for the resolution of (R,S)-ibuprofen: Chiral HPLC vs achiral HPLC linked to an optical rotation detector

Autor:	Michael Trani, Amélie Ducret, Robert Lortie, P. Pepin
Rok vydání:	1995
Předmět:	Chromatography Resolution (mass spectrometry) Chemistry Detector Enantioselective synthesis Ibuprofen Applied Microbiology and Biotechnology Biochemistry High-performance liquid chromatography Chiral column chromatography Yield (chemistry) medicine Optical rotation medicine.drug
Zdroj:	Biotechnology Techniques. 9:591-596
ISSN:	1573-6784 0951-208X
Popis:	Two approaches have been used to monitor the enantioselective esterification of (R,S)-ibuprofen with 1-dodecanol catalyzed by Novozym 435. The first approach involves the use of a chiral column (Chiralcel OD) connected to a UV detector. The second approach involves using a C-18 reversed-phase column connected in series to a RI detector and to an Optical Rotation detector. The two methods yield the same results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9263f1656b026d2d6293e76d25c8bc6b https://doi.org/10.1007/bf00152450 Zobrazit plný text záznamu Full text from SpringerLink