On the formation of estrone lactam esters ofN,N-bis(2-chloroethyl)aminocinnamic acid isomers,p-N,N-bis(2-chloroethyl)aminophenylbutyric acid and their antitumor activity

Autor:	G. Pairas, Panayotis Catsoulacos, A. Papageorgiou
Rok vydání:	1995
Předmět:	Antitumor activity Cell kinetics chemistry.chemical_compound chemistry In vivo Stereochemistry Organic Chemistry Lactam Estrone P388 leukemia neoplasms In vitro
Zdroj:	Journal of Heterocyclic Chemistry. 32:1063-1065
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570320365
Popis:	New estrone-lactam esters, 17α-aza-D-homo-Δ1,3,5(10)-estratrien-3-ol-17-one-N,N-bis(2-chloroethyl)-aminocinnamic isomers and p-N,N-bis(2-chloroethyl)aminophenylbutyrate have been synthesized and tested in P388 leukemia in vivo and P388 and L1210 leukemias in vitro. The effect of these compounds on SCE rates and on cell kinetics in cultured human lymphocytes was studied also.
Databáze:	OpenAIRE
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