Super-efficient in Vivo Two-Photon Photodynamic Therapy with a Gold Nanocluster as a Type I Photosensitizer
| Autor: | Yuankai Hong, Lu Huang, Helin Liu, Shengcang Zhu, Zhi-Wei Wang, Yinlin Sha, Yu Wang, Rongcheng Han, Miao Zhao, Yuqiang Jiang, Lijun Wang |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Therapeutic Technique Chemistry medicine.medical_treatment General Engineering General Physics and Astronomy Photodynamic therapy 02 engineering and technology In vivo toxicity 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Dihydrolipoic acid Two-photon excitation microscopy In vivo medicine Biophysics General Materials Science Photosensitizer 0210 nano-technology |
| Zdroj: | ACS Nano. 14:9532-9544 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.9b05169 |
| Popis: | Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic technique that can induce the regression of targeted lesions via generating excess cytotoxic reactive oxygen species. However, due to the limited penetration depth of visible excitation light and the intrinsic hypoxia microenvironment of solid tumors, the efficacy of PDT in the treatment of cancer, especially deep-seated or large tumors, is unsatisfactory. Herein, we developed an efficient in vivo PDT system based on a nanomaterial, dihydrolipoic acid coated gold nanocluster (AuNC@DHLA), that combined the advantages of large penetration depth in tissue, extremely high two-photon (TP) absorption cross section (σ2 ∼ 106 GM), efficient ROS generation, a type I photochemical mechanism, and negligible in vivo toxicity. With AuNC@DHLA as the photosensitizer, highly efficient in vivo TP-PDT has been achieved. |
| Databáze: | OpenAIRE |
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