Action of lipases on low-density serum lipoproteins

Autor:	Shpikiter Vo, Karmanskiĭ Im
Rok vydání:	1977
Předmět:	Intermediate-density lipoprotein Proteases biology Chemistry Serum albumin General Medicine General Biochemistry Genetics and Molecular Biology Residue (chemistry) Phospholipase A2 Biochemistry biology.protein Lipolysis lipids (amino acids peptides and proteins) Lipase Solubility
Zdroj:	Bulletin of Experimental Biology and Medicine. 84:1125-1127
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00799196
Popis:	During the action of phospholipase A2 on low-density serum lipoproteins (LDL) in the presence of serum albumin as adsorbent for low-molecular-weight products of lipolysis a change takes place in the physicochemical properties of the LDL, expressed as a decrease in their flotation coefficients. Lipase hydrolyzes the triglycerides of LDL after preliminary treatment of the latter with phospholipase A2. Under the influence of lipases the LDL residue becomes insoluble and a cholesterol-rich precipitate is formed. Loss of solubility of lipoproteins following treatment with lipases and proteases may take place in certain states in vivo and may provide the basis for the formation of atheromas, i.e., it may be one of the factors in the pathogenesis of atherosclerosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::924e192fbc4752509cafd366f325f5ad https://doi.org/10.1007/bf00799196 Zobrazit plný text záznamu Full text from SpringerLink