Cardiac MRI assessment of the right ventricle pre-and post-kidney transplant

Autor: Djeven P. Deva, Gauri R. Karur, Michelle M. Nash, Kim A. Connelly, Weiqiu Yuan, Philip W. Connelly, S. Joseph Kim, Rachel M. Wald, G. V. Ramesh Prasad, Lakshman Gunaratnam, Charmaine E. Lok, Abdulaziz Ahmed Hashi, Andrew T. Yan, Ron Wald
Rok vydání: 2021
Předmět:
Zdroj: The International Journal of Cardiovascular Imaging. 37:1757-1766
ISSN: 1573-0743
1569-5794
Popis: Worsening renal function in chronic kidney disease correlates with worsening right ventricular (RV) systolic function. We evaluated the association between kidney transplantation (KT) and RV structure and systolic function, and the relationships between RV and left ventricular (LV) changes, blood pressure, and specific cardiac biomarkers, in patients with end-stage kidney disease using cardiac magnetic resonance imaging (CMR). In this prospective, multi-centre, cohort study, 39 adult patients on dialysis receiving KT and 42 patients eligible for, but not yet receiving KT, were recruited. CMR was performed at baseline, and repeated at 12 months. Among 81 patients (mean age 51 years, 30% female), RV end-diastolic volume index (RVEDVi), end-systolic volume index (RVESVi), mass index (RVMi), and ejection fraction (RVEF) did not change significantly within either the dialysis or KT group over 12 months (all p ≥ 0.10). There were no significant differences in the 12-month changes of these parameters between the dialysis and KT groups (all p ≥ 0.10). RVMI demonstrated positive correlations with NT-proBNP and systolic blood pressure, but not GDF-15, at baseline and at 12 months. Changes in RVEDVi, RVESVi, and RVEF were positively correlated with changes in LVEDVi, LVESVi, and LVEF, respectively over 12 months (Spearman r = 0.72, 0.52, and 0.41; all p
Databáze: OpenAIRE
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