Preparation and in vitro evaluation of PEGylated liposomes as effective nanocarrier for delivery of oxaliplatin
| Autor: | Ngoc Thuy Trang Le, Dai Hai Nguyen, Anh-Minh Nguyen-Huu, Ngoc Hoi Nguyen, Minh Thanh Vu |
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| Rok vydání: | 2021 |
| Předmět: |
010302 applied physics
Liposome Materials science Mechanical Engineering Vesicle 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Oxaliplatin chemistry.chemical_compound chemistry Mechanics of Materials 0103 physical sciences Biophysics Zeta potential PEGylation medicine General Materials Science Nanocarriers 0210 nano-technology Cytotoxicity Ethylene glycol medicine.drug |
| Zdroj: | Journal of Materials Research. 36:475-486 |
| ISSN: | 2044-5326 0884-2914 |
| DOI: | 10.1557/s43578-021-00105-9 |
| Popis: | The effectiveness of using PEGylated soy lecithin liposome in oxaliplatin (OXA) delivery was investigated. Liposomes were prepared from soy lecithin, cholesterol, and methoxy poly(ethylene glycol)-cholesterol by thin lipid film hydration. The obtained OXA-loaded PEGylated liposome was characterized as ~ 189 nm diameter spheroid-like vesicles, negative charge, and drug-loading efficiency of ~ 44%. The nanocarrier exhibited in vitro sustained release patterns with ~ 31% of the initial drug was released in 24 h. The colloidal systems showed excellent stability in terms of particle size, polydispersity index, and zeta potential when being stored for 30 days at 2–8 °C. Moreover, the in vitro cytotoxicity assays revealed that PEGylated liposomes could enhance the activity of OXA on human breast cancer cells MCF-7 and reduced the cytotoxicity of OXA on mouse fibroblast cells L929. These results indicated that OXA-loaded PEGylated liposome has great potential in antitumor treatment. PEGylated liposomes enhanced in vitro stability and oxaliplatin delivery > |
| Databáze: | OpenAIRE |
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