Changes in the Activity of the Ciliary Apparatus of Ependymal Cells in the Midbrain Cerebral Aqueduct Induced by a Number of Cerebrospinal Fluid Neurotransmitters

Autor:	N. N. Gvinadze, E. V. Didimova, I. K. Svanidze
Rok vydání:	2011
Předmět:	medicine.medical_specialty Ependymal Cell General Neuroscience Glutamate receptor Strychnine Bicuculline Midbrain chemistry.chemical_compound Endocrinology Cerebrospinal fluid chemistry Internal medicine Cerebral aqueduct medicine Neurotransmitter medicine.drug
Zdroj:	Neuroscience and Behavioral Physiology. 42:72-74
ISSN:	1573-899X 0097-0549
DOI:	10.1007/s11055-011-9536-0
Popis:	Studies of the effects of neurotransmitter amino acids on the motor activity of the ciliary apparatus of ependymal cells of the midbrain cerebral aqueduct in neonatal white mice showed that addition of glutamate, GABA-aminobutyric acid, glycine, and taurine to the culture medium induced slowing and then complete cessation of the activity of the ciliary apparatus. Inhibition and cessation of the activity of cilia in response to neurotransmitters, especially glutamate at high concentrations, demonstrated the existence of the corresponding receptors on the membranes of ependymal cells in the cerebral aqueduct, and this was supported by experiments with prior addition of ion channel blockers to the growth medium, i.e., ketamine, strychnine, and bicuculline, which weakened the destructive influences of neurotransmitters and increased the duration of functioning of the ciliary apparatus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9243fbf5529be52585913e2bb37372be https://doi.org/10.1007/s11055-011-9536-0 Zobrazit plný text záznamu Full text from SpringerLink