Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the Amino Terminal, the Central Core and the Carboxyl Terminal of the Molecule
| Autor: | P. S. Barnett, A. M. Mcgregor, M. J. Page, J. P. Banga, D. L. Ewins |
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| Rok vydání: | 1991 |
| Předmět: |
endocrine system
biology Chemistry medicine.medical_treatment Thyroid Autoantibody food and beverages hemic and immune systems Epitope Exon fluids and secretions medicine.anatomical_structure Biochemistry Antigen Thyroid peroxidase Complementary DNA embryonic structures medicine biology.protein Thyroglobulin |
| Zdroj: | Autoimmune Thyroiditis ISBN: 9783540534761 |
| DOI: | 10.1007/978-3-642-76301-4_15 |
| Popis: | The occurrence of autoantibodies (aAbs) to thyroid proteins is a feature of autoimmune thyroid disease (AITD) and a common serological marker for disease activity [1]. Although their precise role in the aetiology of AITD remains speculative, considerable evidence has accumulated to the effect that aAbs to the thyroid microsome/thyroid peroxidase antigen (TMA/TPO) may be pathogenetic [2]. TPO is a well-characterized enzyme involved in the generation of thyroid hormones from thyroglobulin and comprises a 105-kDa protein [3] which has recently been cloned [4]. Two forms of TPO cDNA have been reported, termed TPO-1 and TPO-2, with exon 10 coding for 57 amino acids is spliced from the coding sequence of the shorter TPO-2 cDNA [5]. |
| Databáze: | OpenAIRE |
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