Revisiting the role of serum progesterone as a test of ovulation in eumenorrheic subfertile women: a prospective diagnostic accuracy study
| Autor: | Aleyamma T Kunjummen, Parimala Chinta, Mohan S Kamath, Grace Rebekah |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty 030219 obstetrics & reproductive medicine Obstetrics business.industry media_common.quotation_subject Ultrasound Obstetrics and Gynecology Diagnostic accuracy Serum progesterone medicine.disease Likelihood ratios in diagnostic testing 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Reproductive Medicine medicine business Ovulation Menstrual cycle Kappa media_common |
| Zdroj: | Fertility and Sterility. 114:1315-1321 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2020.06.030 |
| Popis: | Objective To estimate the prevalence of ovulatory cycles in eumenorrheic subfertile women and compare the diagnostic accuracy of a single ultrasound with serum midluteal progesterone measurement in detecting ovulatory cycles. Design Prospective diagnostic accuracy study. Setting University-level hospital. Patient(s) A total of 208 subfertile eumenorrheic women. Intervention(s) None. Main Outcome Measure(s) To estimate the prevalence of ovulatory cycles in eumenorrheic women and compare the diagnostic accuracy of a single, well-timed ultrasound scan (index test) with serum progesterone measurement (reference test) by calculating the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive likelihood ratio (LR+) and negative likelihood ratio (LR–). Result(s) The prevalence of ovulatory cycles among subfertile eumenorrheic women was 92.9% and 99.5% when midluteal serum progesterone level and ultrasound scanning were used as the reference test, respectively. The sensitivity, specificity, PPV, and NPV of ultrasound in identifying ovulatory cycles were 100%, 7.1%, 93.4%, and 100%, respectively. The LR+ and LR− were 1.1 and 0, respectively. The agreement between the ultrasound and serum progesterone was almost perfect (prevalence and bias-adjusted kappa = 0.81. Conclusion(s) The prevalence of ovulatory cycles in eumenorrheic subfertile women appears to be high. A single well-timed ultrasound can be performed to identify ovulatory cycles during the infertility workup in eumenorrheic women. |
| Databáze: | OpenAIRE |
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