Human Melioidosis Caused by Novel Transmission of Burkholderia pseudomallei from Freshwater Home Aquarium, United States1
| Autor: | Jay E. Gee, Patrick Dawson, Denise Sockwell, Monique Duwell, Mindy G. Elrod, David D. Blaney, David A. Crum, Alex R. Hoffmaster, Johanna S. Salzer, Cari B. Kolton, Lindy Liu, Ruth J Thompson, LaToya Griffin Thomas, Zachary P. Weiner, William A. Bower, Ruth M Jacobs |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Whole genome sequencing medicine.medical_specialty Melioidosis biology Epidemiology Burkholderia pseudomallei Transmission (medicine) Public health Clinical course Select agent biology.organism_classification medicine.disease Microbiology Infectious Diseases One Health medicine |
| Zdroj: | Emerging Infectious Diseases. 27:3030-3035 |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Nearly all cases of melioidosis in the continental United States are related to international travel to areas to which Burkholderia pseudomallei, the bacterium that causes melioidosis, is endemic. We report the diagnosis and clinical course of melioidosis in a patient from the United States who had no international travel history and the public health investigation to determine the source of exposure. We tested environmental samples collected from the patient's home for B. pseudomallei by PCR and culture. Whole-genome sequencing was conducted on PCR-positive environmental samples, and results were compared with sequences from the patient's clinical specimen. Three PCR-positive environmental samples, all collected from a freshwater home aquarium that had contained imported tropical fish, were a genetic match to the clinical isolate from the patient. This finding suggests a novel route of exposure and a potential for importation of B. pseudomallei, a select agent, into the United States from disease-endemic areas. |
| Databáze: | OpenAIRE |
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