Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1
| Autor: | Roberta Foresti, James Clark, Padmini Sarathchandra, David J. Exon, Martin J. J. Vesely, Ivan A. Sammut, Roberto Motterlini, Colin J. Green |
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| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
medicine.medical_specialty Aorta Oxygenase biology Carbon monoxide-releasing molecules Nitric oxide Contractility Nitric oxide synthase chemistry.chemical_compound Endocrinology chemistry Biochemistry Internal medicine medicine.artery medicine biology.protein medicine.symptom Phenylephrine Vasoconstriction medicine.drug |
| Zdroj: | British Journal of Pharmacology. 125:1437-1444 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/sj.bjp.0702212 |
| Popis: | The contribution of haeme oxygenase-derived carbon monoxide (CO) to the regulation of vascular tone in thoracic aorta was investigated following induction of the inducible isoform of haeme oxygenase (HO-1). Isometric smooth muscle contractions were recorded in isolated rat aortic ring preparations. Rings were incubated in the presence of the nitric oxide (NO) donor S-nitroso-N-acetyl penicillamine (SNAP, 500 microM) for 1 h, then repetitively washed and maintained for a further 4 h prior to producing a concentration-response curve to phenylephrine (PE, 1-3000 nM). Treatment with SNAP resulted in increased mRNA and protein expression of aortic HO-1 and was associated with a significant suppression of the contractile response to PE (P |
| Databáze: | OpenAIRE |
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