Changes in local blood flows of the solitary kidney in partial disturbances of the autonomic innervation
| Autor: | N. A. Onishchenko, Kot Ag, É. F. Barinov |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Cerebellum Lipid peroxide Vitamin E medicine.medical_treatment Ischemia General Medicine Hypoxia (medical) Mitochondrion medicine.disease General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Medulla oblongata medicine.symptom |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 107:305-307 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00842040 |
| Popis: | The paper studies intensification of lipid peroxide oxidation in separate brain structures (the medulla oblongata, cerebellum, visual and sensomotor cortex), synaptosomal and mitochondrial fractions under hypoxia. It has been established that acute hypoxia increases accumulation of lipid peroxidation (LPO) products, hydroperoxide and malonyl dialdehyde. Intensification of LPO in synaptosomes and mitochondria is more pronounced as compared to the whole structures. Preliminary treatment with antioxidants (vitamin E and ionol) considerably suppressed LPO intensity under both hypoxia and hypoxia with reoxygenation. Intensification of LPO in synaptosomes and mitochondria is suggested to be the key point in structural-functional disturbances of the nervous system under hypoxia and ischemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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