| Autor: |
Thierry Dubuffet, Marie-Odile Vallez, Gilbert Lavielle, Tony Verbeuren, Jean-Jacques Descombes, Serge Simonet |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Advances in Experimental Medicine and Biology ISBN: 9781489918123 |
| DOI: |
10.1007/978-1-4899-1810-9_35 |
| Popis: |
Thromboxane (TXA2) causes platelet aggregation, vasoconstriction and cell proliferation through the activation of specific cell membrane TP-receptors1, 2. TXA2 is implicated in thrombotic disorders and TP-receptor antagonists have been described as an anti-thrombotic approach3. S 18204 (Fig. 1) is a recently developed orally active and long acting TP-receptor antagonist4. Since S 18204 is a racemic compound, the aim of this study was to select the active isomer (S 18885 or S 18886) of S 18204 on platelet and contractile responses induced by the TP-receptor agonist U 46619 under in vitro, in vivo and ex vivo conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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