| Popis: |
Background: Colon cancer is a common malignant disease of the gastrointestinal tract and usually occurs at the junction of the rectum and sigmoid colon. Lymphatic and hematogenous metastases occur frequently in colon cancer and the most common metastatic sites include the regional liver, lung, peritoneum, bone, and lymph nodes. As a manifestation of advanced tumor spread and metastasis, soft tissue metastasis, especially skeletal muscle metastasis ossification caused by colon cancer, is rare, accounting for less than 1% of metastases.Case presentation: In this study, we report a rare case of a 43-year-old male patient who developed an ossifying skeletal muscle metastasis of the right proximal thigh with severe pain at 5 months after colon cancer was diagnosed, who subsequently from the developed metastasis. The patient was admitted to the hospital because of pain caused by a local mass on his right thigh. Positron emission tomography-computed tomography showed multiple lymphadenopathy metastases around the abdominal aorta without lung or liver metastases. Color ultrasound revealed a mass located in the skeletal muscle and the results of histological biopsy revealed a poorly differentiated adenocarcinoma suspected to be distant metastases from colon cancer and immunohistochemistry showed small woven bone components that were considered to be ossified. Conclusion: Although ossifying skeletal muscle metastases is rare, its potential malignancy is high. With advances in examinations and treatment modality, Positron emission tomography-computed tomography, collagen gel droplet culture drug-sensitivity test and genetic tests are recommended to optimize comprehensive and individual treatment modality to prolong patient survival. |
