Über biologische Wirkungen von Koordinationsverbindungen der übergangsmetalle 1. Antivirale Wirkung von 2-Aminopyridinkomplexen des Palladiums

Autor:	Bodo Heyn, Emil Tonew, Marion Tonew, Brunhilde Gumpert, Hans-Peter Schröer
Rok vydání:	1981
Předmět:	biology viruses RNA Pseudorabies RNA virus biology.organism_classification Virology In vitro Virus chemistry.chemical_compound chemistry Mengovirus Vaccinia DNA
Zdroj:	Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale. A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie. 249:296-301
ISSN:	0174-3031
DOI:	10.1016/s0174-3031(81)80086-8
Popis:	Some aminopyridine complexes of palladium and PdCl 2 showed an antiviral in vitro activity against enveloped DNA and RNA viruses such as vaccinia virus, Pseudorabies virus, NDV and FPV. In contrast, naked RNA virus as mengovirus was not affected. The compounds were compatible for chicken embryo as well as FL cells in concentrations of 100–250 μM. The therapeutical index calculated from the maximally tolerated dose and the concentration causing a 50 per cent plaque reduction was determined with more than 45 for vaccinia virus, for example.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::92285d24cca82825f127750d1fd871e3 https://doi.org/10.1016/s0174-3031(81)80086-8 Zobrazit plný text záznamu