| Popis: |
Cryptenamine has been reported to have a more favorable ratio of emetic to hpotensive dose than other veratrum preparations, and the advantageous ratio has geen attributed to the presence of new hypotensive alkaloids. Cryptenamine was fractionated with the aid of partition column chromatography, adsorption column chromatography, and paper partition chromatography. The known hypotensive alkaloids protoveratrine A, protoveratrine B, germitrine, neogermitrine, germerine, and germidine were isolated. In addition, the relatively nonhypotensive alkaloids jervine, rubijervine, isorubijervine, and an apparently new noncarbonyl alkamine were obtained. Paper chromatographic evidence suggesting the presence of the hypotensive alkaloids germbudine and neogermbudine and the relatively nonhypotensive veratramine was also obtained. |
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