Two multi-step selection procedures with Possible selection of two treatments of equal prior preference

Autor:	T. Timothy Chen, Richard Simon
Rok vydání:	1994
Předmět:	Statistics and Probability Binomial distribution Sample size determination Statistics Prior probability Multiple treatments Monotonic function Factorial experiment Selection (genetic algorithm) Preference Mathematics
Zdroj:	Communications in Statistics - Theory and Methods. 23:781-801
ISSN:	1532-415X 0361-0926
DOI:	10.1080/03610929408831286
Popis:	Dunnett's many-one test to compare several experimental treatment means with a control was extended in our previous paper to a decision procedure for selecting a desirable treatment when there is a strictly monotonic prior preference among the multiple treatments due to other consideration such as toxicity or cost. In this paper, we consider the case where two treatments could have equal prior preference. This formulation includes the problem of comparing a combination with its two components, or the comparison of four arms in a 2 by 2 factorial experiment. Our decision procedures will guarantee a high selection probability for the correct treatment(s) when that selection is appropriate. We establish sample size requirements for our decision procedures which can be applied to clinical trials with normal, binomial, or right censored exponential endpoints.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::920bb88806c5c00a1551ea2e4bb1a4a5 https://doi.org/10.1080/03610929408831286 Zobrazit plný text záznamu