A Study to Evaluate KM / Propofol versus KM Alone for Procedural Sedation in Children
| Autor: | Turki Jafar Abdulmajid, Abdulrahman Fayez Kinsara, Basem Abdullah Alghamdi, Qusai Abdullah Al Saqabi, Fawaz Sulaiman Ayed Alshammari, Badr Wadee S Abulhamail, Rakan Abdulrahman Alrzoq, Motaz Ashoor, Basim Salman W Almazrui, Randa Fahad Almatrafi, Ahmad Abdulaziz M. Almehmadi |
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| Rok vydání: | 2017 |
| Předmět: |
Nausea
business.industry Sedation medicine.medical_treatment 030208 emergency & critical care medicine law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Anesthesia Procedural sedation and analgesia medicine Ketamine In patient 030212 general & internal medicine medicine.symptom Adverse effect Propofol business medicine.drug |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 69:2981-2985 |
| ISSN: | 2090-7125 1687-2002 |
| Popis: | Background: The co-administration of ketamine and propofol (CoKP) is thought to maximize the beneficial profile of each medication, while minimizing the respective adverse effects of each medication. Objective: Our objective was to compare adverse events between ketamine monotherapy (KM) and CoKP for procedural sedation and analgesia (PSA) in a pediatric emergency department (ED). Methods: This was a prospective, randomized, single-blinded, controlled trial of KM vs. CoKP in patients between 3 and 21 years of age. The attending physician administered either ketamine 1 mg/kg i.v. or ketamine 0.5 mg/kg and propofol 0.5 mg/kg i.v. The physician could administer up to three additional doses of ketamine (0.5 mg/kg/dose) or ketamine/propofol (0.25 mg/kg/dose of each). Adverse events (e.g., respiratory events, cardiovascular events, unpleasant emergence reactions) were recorded. Secondary outcomes included efficacy, recovery time, and satisfaction scores. Results: Thirty-two patients were randomized to KM and 29 patients were randomized to CoKP. There was no difference in adverse events or type of adverse event, except nausea was more common in the KM group. Efficacy of PSA was higher in the KM group (99%) compared to the CoKP group (90%). Median recovery time was the same. Conclusions: We found no significant differences in adverse events between the KM and CoKP groups. While CoKP is a reasonable choice for pediatric PSA, our study did not demonstrate an advantage of this combination over KM. |
| Databáze: | OpenAIRE |
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