Determination of Quinine, Quinidine, and Cinquinidine by Capillary Electrophoresis

Autor:	Dorota Prukała, Mariusz Kluska, Anna Marciniuk-Kluska, Wiesław Prukała
Rok vydání:	2015
Předmět:	Quinidine Quinine Chromatography Chemistry Clinical Biochemistry Analytical chemistry Pharmaceutical Science Time optimal Biochemistry Analytical Chemistry Electrophoresis Capillary electrophoresis medicine Isotachophoresis Ternary operation medicine.drug
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 38:886-890
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826076.2014.982869
Popis:	This article presents the results of the research on a newly developed methodology for the separation and determination of quinine and its two derivatives. The analyzed compounds are biologically active, which are used in the treatment of malaria. The mixture of the analyzed compounds, i.e., hydrochlorides: quinidine, quinine, and cinquinidine, was dissolved in water and then exposed to optimization of separation and determination by isotachophoresis. The analysis was conducted with a varying number of steps and varying time of analysis, different intensities and voltages of the electric current, and different high voltage limits. For the ternary mixture, the optimal time of analysis was just over 8 min. On the other hand, the determination of cinquinidine had the shortest time of analysis (less than 3 min). The conducted validation of the developed methodology indicates very good conditions for the determination of quinidine, quinine, and cinquinidine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::920339824db4e11818362e99db2b9b54 https://doi.org/10.1080/10826076.2014.982869 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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