An Evaluation of the Acute in Vivo Toxicity of Benzylidenechroman-4-Ones, L-Thiobenzylidenechroman-4-Ones and Benzylidenetetralones

Autor:	Mary J. Meegan, Suhaila Rashid, Tahsin M. Al-Nakib, Nicholas J. Miller
Rok vydání:	1990
Předmět:	Pharmacology Antifungal Chemical Health and Safety medicine.drug_class Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health General Medicine In vivo toxicity Biology Toxicology Acute toxicity medicine Potential source
Zdroj:	Drug and Chemical Toxicology. 13:195-207
ISSN:	1525-6014 0148-0545
DOI:	10.3109/01480549009018120
Popis:	A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis 1 and antifungal activity 2 have previously been described by us. The naturally occurring class of compounds to which they belong—the benzylidenechroman-4-ones—have been identified as a potential source of new antifungal agents 3. These compounds were found to be less toxic, as judged by acute toxicity, than existing commercially available antifungals. A number of conclusions can be drawn about the relationship of structural changes in this series of compounds to increases or decreases in acute toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::91fe67d5788acac5143ae6d07e4d45d2 https://doi.org/10.3109/01480549009018120 Zobrazit plný text záznamu