Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant
| Autor: | Xuefeng Zhang, David A. Nielsen, Thomas R. Kosten, Coreen B. Domingo, Daryl Shorter, Ellen M. Nielsen |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
business.industry Antagonist Genetic variants Medicine (miscellaneous) Alpha (ethology) Pharmacology urologic and male genital diseases 03 medical and health sciences Psychiatry and Mental health Clinical Psychology 030104 developmental biology 0302 clinical medicine Urine toxicology Doxazosin medicine Cocaine use business 030217 neurology & neurosurgery Pharmacogenetics medicine.drug Functional polymorphism |
| Zdroj: | The American Journal of Drug and Alcohol Abuse. 46:184-193 |
| ISSN: | 1097-9891 0095-2990 |
| Popis: | Background: The α1 antagonist doxazosin reduces cocaine use in individuals with cocaine use disorder (CUD) through a functional polymorphism of the α1 adrenoreceptor. The regulatory role of the α1 ... |
| Databáze: | OpenAIRE |
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