Effekt von Koffein auf den myokardialen Blutfluss unter pharmakologischer Vasodilatation
| Autor: | Dieter Horstkotte, J. P. Wielepp, Eva Fricke, Wolfgang Burchert |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
business.industry
Coronary flow reserve Vasodilation Blood flow Decaffeinated coffee medicine.disease Adenosine Coronary artery disease chemistry.chemical_compound Coronary circulation medicine.anatomical_structure chemistry Anesthesia medicine Cardiology and Cardiovascular Medicine Caffeine business medicine.drug |
| Zdroj: | Zeitschrift f�r Kardiologie. 94:128-132 |
| ISSN: | 1435-1285 0300-5860 |
| DOI: | 10.1007/s00392-005-0173-x |
| Popis: | Pharmacologic stress with adenosine is frequently used for noninvasive detection of coronary artery disease. Dietary intake of caffeinated food, beverages or medications might alter adenosine-induced hyperemic blood flow, thereby compromising the diagnostic sensitivity of adenosine stress testing. In this case we report on a male patient with CAD. Myocardial blood flow at rest and during adenosine-induced hyperemia 2 hours after consumption of decaffeinated coffee and again without caffeine intake were quantified by ammonia PET. After caffeine intake there was a clearly diminished increase of myocardial blood flow during adenosine. The average coronary flow reserve in the myocardium was 1.3 after caffeine. In the baseline study without caffeine the coronary flow reserve has been improved to 2.3. Caffeine intake alters the coronary vasodilatory capacity. These findings emphasize the importance of carefully screening patients for intake of caffeinated food prior to adenosine stress testing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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