Metabolic Regulation in Mitochondria and Drug Resistance
| Autor: | Gary Guishan Xiao, Paul W. N. Lee, Vay Liang W. Go, Jianzhou Liu, Xiaoyu Miao, Yue Pan, Qing Yang, Min Cao |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell Cancer Biology Mitochondrion medicine.disease Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology The Hallmarks of Cancer medicine.anatomical_structure chemistry Cancer cell medicine Signal transduction Reprogramming Adenosine triphosphate |
| Zdroj: | Mitochondrial DNA and Diseases ISBN: 9789811066733 |
| DOI: | 10.1007/978-981-10-6674-0_11 |
| Popis: | Mitochondria are generally considered as a powerhouse in a cell where the majority of the cellular ATP and metabolite productions occur. Metabolic rewiring and reprogramming may be initiated and regulated by mitochondrial enzymes. The hypothesis that cellular metabolic rewiring and reprogramming processes may occur as cellular microenvironment is disturbed, resulting in alteration of cell phenotype, such as cancer cells resistant to therapeutics seems to be now acceptable. Cancer metabolic reprogramming regulated by mitochondrial enzymes is now one of the hallmarks of cancer. This chapter provides an overview of cancer metabolism and summarizes progress made in mitochondria-mediated metabolic regulation in cancer drug resistance. |
| Databáze: | OpenAIRE |
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