Synthesis of Novel Benzimidazole-2-carboxamide Derivatives and in Vivo Antihyperlipidemic Activity Evaluation
| Autor: | Majdi M. Bkhaitan, Hanin Moh'd Kalloush, Tariq Al-Qirim, Reema Abu Khalaf, Yusuf Al-Hiari, Lama Hamadneh, Ghassan Abu Sheikha |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Benzimidazole
Chemistry Serum lipid levels medicine.drug_class Carboxamide Biological activity General Chemistry General Medicine 030204 cardiovascular system & hematology Pharmacology medicine.disease 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Drug Discovery Hyperlipidemia Plasma lipids medicine Benzophenone |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 66:423-426 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Hyperlipidemia is known as an elevation of plasma lipid components. It contributes significantly to atherosclerosis which is one of the most important causative factors in cardiovascular diseases. Agents that cause a dramatic decrease in serum lipid levels are of great value in the treatment of cardiovascular diseases. For this purpose, a new series of benzimidazole propyl carboxamide benzophenone derivatives have been synthesized (7, 8, and 9). These compounds were tested in vivo to evaluate their potential hypolipidemic activity using Triton WR-1339 induced hyperlipidemic rats. All the synthesized compounds have proved to be highly biologically active, with compound 9 being the most active derivative. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|