NOS3 Gene rs1799983 and rs2070744 Polymorphisms in Patients with Unstable Angina
| Autor: | Agnieszka Maciejewska-Skrendo, Violetta Dziedziejko, Andrzej Pawlik, Krzysztof Safranow, Monika Rać, Halina Błaszczyk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Acute coronary syndrome Physiology NOS1 030204 cardiovascular system & hematology Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enos Internal medicine Genotype medicine cardiovascular diseases biology business.industry Unstable angina biology.organism_classification medicine.disease Coronary arteries Nitric oxide synthase 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry biology.protein Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Vascular Research. 57:136-142 |
| ISSN: | 1423-0135 1018-1172 |
| Popis: | Acute coronary syndrome occurs when the heart muscle does not receive adequate oxygen and nutrients in a timely manner. Acute coronary syndromes are primarily due to atherosclerosis of the coronary arteries, i.e., coronary heart disease. Nitric oxide (NO) is synthesised from L-arginine in endothelial cells by the constitutive calcium-calmodulin-dependent enzyme, nitric oxide synthase (NOS), which mediates endothelium-dependent vasodilatation. Endothelial nitric oxide synthase (eNOS) is predominantly expressed in endothelial cells. Three NOS isoforms have been detected in different tissue: (1) neuronal NOS (nNOS) (NOS1), (2) eNOS (NOS2), and (3) inducible NOS (iNOS) (NOS3). These isoforms are encoded by three different genes. NOS3 is located on chromosome 7q35–36 and contains 26 exons. Previous studies have suggested that NOS3 polymorphisms may be associated with acute coronary syndromes. Therefore, the aim of the study was to examine the associations between NOS3 rs1799983 (894G/T)andrs2070744 (–786T/C) polymorphisms and unstable angina. This study included 246 patients with unstable angina, as confirmed by coronary angiography. We also included 189 healthy controls who were also assessed by this technique. There were no significant differences in genotype distributions of NOS3 rs1799983and rs2070744 polymorphisms in patients with unstable angina and healthy controls in both univariate and multivariate analyses. In patients with the NOS3 rs1799983 TT genotype, we observed a higher BMI (TT vs. GT + GG, p = 0.068), and in patients with the NOS3 rs2070744 TT genotype, we observed a higher waist circumference (TT vs. TC + CC, p = 0.023; TT vs. CC, p = 0.0053). These data suggest a lack of association between the NOS3 rs1799983andrs2070744 polymorphisms and unstable angina in our patient population. However, these polymorphisms may be associated with some obesity parameters, rs1799983 in females and rs2070744 in males. |
| Databáze: | OpenAIRE |
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