Menstrual cycle phase effects on prepulse inhibition of acoustic startle
| Autor: | Tanja Jovanovic, Subhajit Chakravorty, Arti Parwani, John Rotrosen, Erica Duncan, Barbara Lewison, Sandor Szilagyi, Ana M. Fiallos, Stephen Gonzenbach, Marion P. Schwartz |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Cognitive Neuroscience media_common.quotation_subject Experimental and Cognitive Psychology Luteal phase Developmental psychology Developmental Neuroscience Internal medicine Follicular phase Moro reflex medicine Biological Psychiatry Prepulse inhibition Menstrual cycle media_common Sensory gating Endocrine and Autonomic Systems General Neuroscience Menstrual cycle phase Neuropsychology and Physiological Psychology medicine.anatomical_structure Endocrinology Neurology Estrogen Psychology |
| Zdroj: | Psychophysiology. 41:401-406 |
| ISSN: | 0048-5772 |
| Popis: | Prepulse inhibition (PPI) represents an attenuation of the startle reflex following the presentation of a weak prepulse at brief intervals prior to the startle eliciting pulse. It has been shown that increases in striatal dopamine levels decrease PPI; because dopamine release is sensitive to estrogen, it is likely that PPI varies across the menstrual cycle. Cross-sectional studies looking at estrogen effects suggest that this may be true. In this study, we compare effects of menstrual phase on PPI in a between-group design (men, follicular phase women, and luteal phase women) as well as a within-subjects design (women across the two phases). The study found a between-group as well as a within-subjects effect of phase on PPI. PPI in follicular phase women did not differ significantly from PPI in men. However, PPI was reduced in luteal women compared to follicular women. These data provide evidence that ovarian hormones affect sensorimotor gating. |
| Databáze: | OpenAIRE |
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