Effect of CT-based attenuation correction on uptake ratios in skeletal SPECT
| Autor: | Joachim Hornegger, I. Nickel, Werner Bautz, V. Schulz, A. Nömayr, Torsten Kuwert, Carsten Hocke, Alexander Hans Vija, Wolfgang Römer |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Facet (geometry) medicine.diagnostic_test business.industry Attenuation General Medicine Patient data Patient specific Fifth lumbar vertebral body Facet joint medicine.anatomical_structure Bone scintigraphy medicine Radiology Nuclear Medicine and imaging Radiology Nuclear medicine business Correction for attenuation |
| Zdroj: | Nuklearmedizin. 46:38-42 |
| ISSN: | 2567-6407 0029-5566 |
| DOI: | 10.1055/s-0037-1616624 |
| Popis: | SummaryThe aim of this study was to determine the clinical relevance of compensating SPECT data for patient specific attenuation by the use of CT data simultaneously acquired with SPECT/CT when analyzing the skeletal uptake of polyphosphonates (DPD). Furthermore, the influence of misregistration between SPECT and CT data on uptake ratios was investigated. Methods: Thirty-six data sets from bone SPECTs performed on a hybrid SPECT/CT system were retrospectively analyzed. Using regions of interest (ROIs), raw counts were determined in the fifth lumbar vertebral body, its facet joints, both anterior iliacal spinae, and of the whole transversal slice. ROI measurements were performed in uncorrected (NAC) and attenuation-corrected (AC) images. Furthermore, the ROI measurements were also performed in AC scans in which SPECT and CT images had been misaligned by 1 cm in one dimension beforehand (ACX, ACY, ACZ). Results: After AC, DPD uptake ratios differed significantly from the NAC values in all regions studied ranging from 32% for the left facet joint to 39% for the vertebral body. AC using misaligned pairs of patient data sets led to a significant change of whole-slice uptake ratios whose differences ranged from 3,5 to 25%. For ACX, the average left-to-right ratio of the facet joints was by 8% and for the superior iliacal spines by 31% lower than the values determined for the matched images (p |
| Databáze: | OpenAIRE |
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