ARE THERE ESTROGEN-RECEPTORS IN HUMAN LARYNGEAL CANCERS

Autor:	R Ng, J Kellen, Diponkar Banerjee, P Gullane, C Crukley
Rok vydání:	1993
Předmět:	Cancer Research Oncogene medicine.drug_class Estrogen receptor Cancer Biology medicine.disease Monoclonal antibody Molecular medicine Oncology Carcinoma medicine Cancer research Immunohistochemistry Receptor hormones hormone substitutes and hormone antagonists
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.3.1.95
Popis:	The presence of estrogen receptors in laryngeal carcinoma is controversial; with two independent methods (testing the binding of monoclonal antibodies against receptor protein by immunohistochemistry binding of labelled H-3-estradiol with the charcoal-dextran method), the levels of ER were found to be, if any, extremely low and without correlation to age, sex and previous radiation therapy of the patient. Administration of antiestrogens (if rationalized by the presence of ER) is therefore not indicated.
Databáze:	OpenAIRE
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