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Background: The quality of life of patients after percutaneous coronary interventions (PCI) is definitely not clear. The aim of this study was to evaluate the health-related quality of life (HRQL) and related factors in patients undergoing angioplasty. Methods: This analytical cross-sectional study was performed on patients with coronary artery disease who underwent PCI and had a history of hospitalization in Zanjan, Iran in 2020. 920 patients based on specific inclusion and exclusion criteria were included by census method.The study tool was a 36-item Short Form Health Survey questionnaire)SF-36). Mann-Whitney U test and Kruskal-Wallis tests were used to data analysis in SPSS 19 with a significance level of 5%. Results: In total, 70%(644people) were female, 86% (791) angina, 34.2% (315) Myocardial infarction. median (IQR) of age, Physical Component Summary(PCS), and Mental component summary (MCS) were 60 (15), 65.78(9.48), 64.18 (7.68), respectively. Multivariate linear regression showed that PCI type (B=-2.52, p=0.013) and age (B= -0.21,p |