Determination of in vitro hepatotoxicity of two plants of the Apocynaceae family

Autor:	W. Cordier, V. Steenkamp
Rok vydání:	2014
Předmět:	Traditional medicine Apocynaceae biology Apoptosis Toxicity Botany Acokanthera oppositifolia Tabernaemontana elegans Viability assay biology.organism_classification Inner mitochondrial membrane In vitro
Zdroj:	Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie. 33
ISSN:	2222-4173 0254-3486
DOI:	10.4102/satnt.v33i1.1257
Popis:	Determination of in vitro hepatotoxicity of two plants of the Apocynaceae family Although toxicity has been ascribed to Acokanthera oppositifolia and Tabernaemontana elegans, no data exists concerning its potential hepatotoxic effects. Using a multi-parametric assay it was observed that hot water and methanol extracts of A. oppositifolia and T. elegans decreased cell viability, destabilized the mitochondrial membrane and induced strong apoptotic signals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::91b204155c9529eba9ba6d37799e6def https://doi.org/10.4102/satnt.v33i1.1257 Zobrazit plný text záznamu