Gas-chromatographic analysis for therapeutic concentration of imipramine and disipramine in plasma, with use of a nitrogen detector

Autor:	D N Bailey, P I Jatlow
Rok vydání:	1976
Předmět:	Drug Chromatography media_common.quotation_subject Metabolite Biochemistry (medical) Clinical Biochemistry chemistry.chemical_element Liter Pharmacology Nitrogen Imipramine chemistry.chemical_compound chemistry Desipramine medicine In patient media_common medicine.drug Promazine
Zdroj:	Clinical Chemistry. 22:1697-1701
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/22.10.1697
Popis:	We describe a method for the simultaneous gas-chromatographic analysis of imipramine and desipramine (the active N-desmethyl metabolite) at therapeutic concentrations in human plasma, with use of a nitrogen detector. Imipramine is measured as the unchanged base and desipramine as its N-tribluoroacetyl derivative. Promazine is the internal standard. The lower limit of sensitivity is 5 mug/liter for each drug, and the within-day coefficients of variation for the determination of imipramine and desipramine, respectively, are 6.0% and 3.3%. We measured concentrations of these drugs both in patients receiving therapeutic doses of imipramine and in those who had ingested an overdose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::91adffeee10d0dc9c615182f1c427781 https://doi.org/10.1093/clinchem/22.10.1697 Zobrazit plný text záznamu