Differential scanning calorimetry of human and animal stratum corneum membranes
| Autor: | B.W. Barry, S.M Al-Saidan, Adrian C. Williams |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Lagomorpha
integumentary system biology digestive oral and skin physiology Pharmaceutical Science Human skin biology.organism_classification Membrane Differential scanning calorimetry medicine.anatomical_structure Biochemistry Neonatal rabbit Stratum corneum medicine Biophysics lipids (amino acids peptides and proteins) Lipid bilayer Animal species |
| Zdroj: | International Journal of Pharmaceutics. 168:17-22 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/s0378-5173(98)00078-7 |
| Popis: | Thermal transitions in desiccated stratum corneum membranes of neonatal rats, mice and rabbits and adult abdominal human skin were investigated using differential scanning calorimetry (DSC). Four endothermic transitions at 39–45 (T1), 55–58 (Tx), 68–74 (T2) and 77–86°C (T3) were observed. T1, T2 and T3 were attributed to phase changes in the intercellular lipid bilayers. Tx was a weak transition, the exact nature of which is unknown. A fifth transition at 48°C (Ty) was only observed with neonatal rabbit stratum corneum and was attributed to lipid melting. The DSC results indicated that the temperatures of lipid transitions of human and animal tissues were different although the patterns of their thermograms were similar. The temperatures of T2 and T3 of human stratum corneum were higher than those of the animals. DSC of neonatal rabbit stratum corneum showed a lipid transition not seen in stratum corneum of human or other animal species. |
| Databáze: | OpenAIRE |
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