TNF ‐ Α And Glycemic Control in T2D: A Single Center Study
| Autor: | Ahmed Embaby, Adel Ghorab, Ali Mostafa Shendi, Fatima Al Taher, Asmaa Mohamed Hosny Esh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030222 orthopedics
medicine.medical_specialty education.field_of_study biology business.industry C-reactive protein Population Type 2 Diabetes Mellitus Inflammation 030229 sport sciences medicine.disease Gastroenterology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus medicine biology.protein medicine.symptom business education Glycemic |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 80:1074-1078 |
| ISSN: | 2090-7125 |
| Popis: | Background: Type 2 diabetes mellitus (T2D) is a global heath burden that is recently viewed as a state of chronic low-grade inflammation involving activation of immunological and inflammatory responses. Tumor necrosis factor‐ alpha (TNF‐ α) is a well-known pro inflammatory cytokine produced mainly by adipose tissues that plays a predominant role in development of insulin resistance in obese population. Thus, several researchers have hypothesized that circulating TNF‐ α levels in diabetic patients can influence diabetic control Objectives: The aim of the study was to analyse the relationship between the proinflammatory cytokine TNFα, C-reactive protein (CRP), ESR and HbA1c in patients with type2 diabetes mellitus to evaluate the impact of these inflammatory markers on glycemic control. Subjects and methods: This study included eighty-four Type 2 DM patients from patients admitted to internal medicine department in Zagazig University Hospitals. Routine laboratory investigations, TNF -α, ESR, CRP and HbA1c were collected and analyzed in all studied population. Results: We found significant association between serum TNF-α and serum HbA1c. These results supports the impact of TNF-α on glycemic control in T2D patients. Conclusion: Serum TNF-α and CRP levels are elevated in type-2 diabetic patients and their levels correlate with level of HBA1c. This supports the impact of inflammation on glycemic control. |
| Databáze: | OpenAIRE |
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