Design, synthesis and transformation of some heteroannulated 3-aminopyridines—purine isosteres with exocyclic nitrogen atom

Autor:	Andrei A. Tolmachev, Satenik Mkrtchyan, Muhammad S. A. Abbasi, Ani Hakobyan, Alexander Villinger, Dmitriy M. Volochnyuk, Linda Supe, Ashot Gevorgyan, Dmytro Ostrovskyi, Knar Arakelyan, Marcelo Vilches-Herrera, Viktor O. Iaroshenko
Rok vydání:	2013
Předmět:	Purine chemistry.chemical_compound chemistry Design synthesis Nitrogen atom Stereochemistry Aryl Organic Chemistry Drug Discovery Biochemistry Medicinal chemistry Aminopyridines
Zdroj:	Tetrahedron. 69:1217-1228
ISSN:	0040-4020
DOI:	10.1016/j.tet.2012.11.026
Popis:	The synthesis of 1-deazapurines and isosteres bearing the exocyclic nitrogen atom at position-1 was developed basing on the formal [3+3]-cyclization reaction of nitro-malonaldehyde with the set of electron-excessive aminoheterocycles. Through the functionalization of the purine-like scaffolds synthesized the diversity of compounds furnished in the possition-1 with aryl, alkinyl, and vinyl rests, were obtained.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::918ad3b3483e1d0362d6caf455e56b63 https://doi.org/10.1016/j.tet.2012.11.026 Zobrazit plný text záznamu Full Text from ScienceDirect