A New Diterpenoid Against Endometrial Cancer from Sheareria nana

Autor:	Zhengxiang Xia, Zhongyan Tang
Rok vydání:	2021
Předmět:	Chemistry Endometrial cancer Plant Science General Chemistry medicine.disease Molecular biology General Biochemistry Genetics and Molecular Biology Terpenoid Sheareria nana Cell culture Ic50 values medicine Carcinoma Cytotoxic T cell
Zdroj:	Chemistry of Natural Compounds. 57:691-694
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-021-03451-6
Popis:	A new diterpenoid, 15,16,17-trihydroxy,18-carboxylic acid 18-neo-clerodan-3,13-(Z)-diene was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. Compound 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (ECC-1). The results indicated that 1 showed moderate cytotoxic activity against ECC-1 cell lines with IC50 values of 5.6 ± 0.3 and 2.2 ± 0.2 μM for 24 and 48 h, respectively. Taken together, 1 was a good choice for the treatment of endometrial carcinoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::918a61baa6da32b7487560aab3a21260 https://doi.org/10.1007/s10600-021-03451-6 Zobrazit plný text záznamu Plný text ve formátu PDF