Supercritical fluid extraction coupled with chromatography-mass spectrometry: Hair analysis. Chromatography-mass spectrometry data processing using the CODA mathematical algorithm

Autor:	I. N. Glazkov, I. A. Revel’skii, A. V. Bogdanov
Rok vydání:	2007
Předmět:	Data processing Chromatography Chemistry Hair analysis Analytical chemistry Supercritical fluid extraction Sorption Mass spectrometry Algorithm Analytical Chemistry Ion Extractor Coda
Zdroj:	Journal of Analytical Chemistry. 62:63-67
ISSN:	1608-3199 1061-9348
DOI:	10.1134/s1061934807010133
Popis:	The composition of medium-volatility organic compounds extracted from human hair using supercritical fluid extraction (SFE) was determined. The entire extract was trapped from a gas flow in a sorption device at the extractor outlet and thermally desorbed into a gas chromatography-mass spectrometry (GC-MS) instrument. The extracted compounds were identified either by the direct processing of GC-MS data or using the CODA mathematical algorithm. The combination of solventless SFE with the transfer of the entire extract into a GC-MS instrument with the direct analysis of GC-MS data allowed us to determine organic compounds at a level of 3.9 pg/mg hair. The CODA mathematical algorithm for the processing of GC-MS data allowed us to determine compounds at a level of 1.7 pg/mg hair; in the majority of publications, this determination limit was achieved either by selective ion detection or using a GC-MS-MS technique.
Databáze:	OpenAIRE
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