Au(I)/(R)-BINOL–Ti(IV) Concerted Catalyzed Asymmetric Cascade Cycloaddition Reaction of Arylalkynols

Autor:	Tianlong Zeng, Lingyan Liu, Weixing Chang, Jing Li, Hongkai Wang
Rok vydání:	2021
Předmět:	Bicyclic molecule 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Cycloaddition 0104 chemical sciences Catalysis Stereocenter Cascade Yield (chemistry) Physical and Theoretical Chemistry Bimetallic strip
Zdroj:	Organic Letters. 23:3573-3577
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c00976
Popis:	An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new σ bonds and three new stereogenic centers were formed in a one-pot process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::91822e986e36fb3604a5c43e1ce06ced https://doi.org/10.1021/acs.orglett.1c00976 Zobrazit plný text záznamu