Physical activity levels and hepatic steatosis: A longitudinal follow-up study in adults
| Autor: | Raquel D. Conceição, Daniel Umpierre, Raul D. Santos, Aline Mendes Gerage, P. Babu Balagopal, Márcio Sommer Bittencourt, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Hepatology business.industry Gastroenterology Follow up studies Physical activity medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine Nonalcoholic fatty liver disease medicine 030211 gastroenterology & hepatology Steatosis Ultrasonography business Body mass index |
| Zdroj: | Journal of Gastroenterology and Hepatology. 33:741-746 |
| ISSN: | 0815-9319 |
| Popis: | Background and Aim This study aimed to evaluate the impact of physical activity (PA) on the course of hepatic steatosis (HS) in adults. Methods HS status (ultrasonography) and PA levels were evaluated in 5860 subjects at baseline and after approximately 2.5 years (range: 19-50 months). At follow-up possible exposures to different PA levels were: those who remained inactive, became inactive, became active, remained active. After follow-up, subjects were then classified according to the four possible states (outcomes): “remained without HS”, “developed HS” (subjects without HS at baseline), “remained with HS”, or “reverted HS”. Results After multivariate adjustments individuals without HS that became or remained physically active were less likely to develop HS compared to those who remained physically inactive (OR = 0.75; P = 0.04, and 0.75; P = 0.03, respectively). Among those with HS at baseline, becoming and remaining physically active beneficially improved the HS status (OR = 0.64; P = 0.01, and 0.66; P = 0.01, respectively). However, the significance was lost when adjusted for changes in body mass index. Conclusion Higher levels of PA were associated with prevention and treatment of HS, with evidence of effect mediation by changes in body mass index. |
| Databáze: | OpenAIRE |
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