ChemInform Abstract: Synthesis of Fluoroalkylated β-Aminophosphonates and Pyridines from Primary β-Enaminophosphonates

Autor:	Francisco Palacios, Julen Oyarzabal, Ana M. Ochoa de Retana, Sergio Pascual, Guillermo Fernandez de Troconiz
Rok vydání:	2008
Předmět:	Primary (chemistry) Chemistry Sodium chemistry.chemical_element Regioselectivity Fluorine containing Stereoselectivity General Medicine Zinc Combinatorial chemistry Catalytic hydrogenation
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200843178
Popis:	A simple and efficient stereoselective synthesis of fluorine containing β-aminophosphonates by reduction of β-enaminophosphonates is described. Reduction with sodium cyanborohydride in the presence of zinc chloride and the catalytic hydrogenation of β-enaminophosphonates gives β-aminophosphonates. β-Enaminophosphonates are also used as intermediates for the regioselective synthesis of fluoroalkyl-substituted pyridines.
Databáze:	OpenAIRE
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