Adenosine and chronic ischemia of the lower limbs
| Autor: | F. Laghi Pasini, T. Di Perri, Pier Leopoldo Capecchi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
business.industry
Ischemia Vasodilation 030204 cardiovascular system & hematology Pharmacology medicine.disease 030226 pharmacology & pharmacy Adenosine receptor Adenosine Cytoprotection Intermittent claudication 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Anesthesia Buflomedil medicine Ischemic preconditioning medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Vascular Medicine. 5:243-250 |
| ISSN: | 1477-0377 1358-863X |
| DOI: | 10.1177/1358836x0000500408 |
| Popis: | Adenosine is an endogenous nucleoside with multiple biological properties which plays a central role in the pathophysiology of tissue ischemia. Adenosine signals an imbalance between oxygen demand and supply, and it initiates responses to redress such a discrepancy. Besides its vasodilating properties, adenosine possesses anti-platelet and anti-neutrophil activities and provides cytoprotection. Adenosine is presumably the main mediator of the preconditioning phenomenon. During ischemia of the lower limbs, adenosine plays a physiological role by inducing vasodilatation and by preventing microcirculatory failure. Exercise training prolongs claudication distance possibly by inducing pulse increases of adenosine and consequently skeletal muscle preconditioning. Moreover, the adenosine increase which follows the administration of some drugs, such as buflomedil and propionylcarnitine, opens new perspectives in the management of leg ischemia. In fact, the concept arises of an ischemic (exercise-dependent) or pharmacologic preconditioning in the treatment of patients with claudication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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