Selective Separation of Physically Near-Identical Microparticle Mixtures by Interfacial Partitioning
| Autor: | L.A.M. van der Wielen, G. Kwant, R. G. J. M. van der Lans, P. Jauregi, M. A. Hoeben |
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| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Industrial & Engineering Chemistry Research. 40:5815-5821 |
| ISSN: | 1520-5045 0888-5885 |
| DOI: | 10.1021/ie001024h |
| Popis: | Interfacial partitioning is a novel technology for the separation of physically near-identical particles, which are particles with similar densities and similar sizes but different chemical compositions. Different crystals partition differently to the interface of a biphasic system, forming a substantial interfacial layer (the interphase) as well as a sediment. Here, the selective separation of ampicillin and phenylglycine crystal mixtures in liquid biphasic systems is studied as a model system. In a characteristic batchwise experiment in one step under specific but nonoptimized conditions in water/alkanol biphasic systems, most phenylglycine crystals (80−90% of the feed) adsorb at the interface, whereas the majority of ampicillin crystals (80−90% of the feed) sediment. Important process parameters such as the interfacial loading, the feed crystal composition, and the volume ratio of the liquid phases have been identified, and their influence on the partitioning has been studied. We also discuss a possibl... |
| Databáze: | OpenAIRE |
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