Design and synthesis of new thiophene derivatives together with their antitumor evaluations

Autor:	Mahmoud Ali Abdelaziz Mahmoud
Rok vydání:	2015
Předmět:	Stereochemistry Acetylacetone Cancer General Medicine Pyrazole medicine.disease Medicinal chemistry chemistry.chemical_compound chemistry medicine Thiophene Cytotoxicity Liver cancer Triethylamine Acetamide
Zdroj:	European Journal of Chemistry. 6:444-450
ISSN:	2153-2257 2153-2249
DOI:	10.5155/eurjchem.6.4.444-450.1316
Popis:	A series of new thiophene derivatives (3a,b) have been prepared by the reaction of acetylacetone with either cyanoacetanilide or 2-cyano- N -( p -tolyl)acetamide and elemental sulfur in the presence of triethylamine as basic catalyst. The two synthesized compounds were used to further synthesize new thiophene derivatives. The structures of all the newly synthesized products have been established on the basis of analytical and spectral data. The antitumor activity of the newly thiophene derivatives was evaluated against six human cancer cell lines, namely gastric cancer (NUGC), colon cancer (DLD1), liver cancer (HA22T and HEPG2), nasopharyngeal carcinoma (HONE1), breast cancer (MCF) and normal fibroblast cells (WI38).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::916a5a867f57c6e82ed347c6a4834fc1 https://doi.org/10.5155/eurjchem.6.4.444-450.1316 Zobrazit plný text záznamu